Computer-Assisted Behavioral Assessment of Pavlovian Fear Conditioning in Mice
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چکیده
منابع مشابه
Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice.
In Pavlovian fear conditioning, a conditional stimulus (CS, usually a tone) is paired with an aversive unconditional stimulus (US, usually a foot shock) in a novel context. After even a single pairing, the animal comes to exhibit a long-lasting fear to the CS and the conditioning context, which can be measured as freezing, an adaptive defense reaction in mice. Both context and tone conditioning...
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Six experiments used rats to study blocking and unblocking of fear learning. An excitatory stimulus (A) blocked fear learning to a neutral stimulus (B). Unblocking of B occurred if the AB compound signaled an increase in unconditioned stimulus (US) intensity or number. Assessments of associative change during blocking showed that more was learned about B than A. Such assessments during unblocki...
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Learning the relationships between aversive events and the environmental stimuli that predict such events is essential to the survival of organisms throughout the animal kingdom. Pavlovian fear conditioning is an exemplar of this form of learning that is exhibited by both rats and humans. Recent years have seen an incredible surge in interest in the neurobiology of fear conditioning. Neural cir...
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Pavlov (1927/1960) reported that following the conditioning of several stimuli, extinction of one conditioned stimulus (CS) attenuated responding to others that had not undergone direct extinction. However, this secondary extinction effect has not been widely replicated in the contemporary literature. In three conditioned suppression experiments with rats, we further explored the phenomenon. In...
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The purpose of this review is to bring to the attention of neuroscientists some of the current thinking of psychologists who study learning processes from a behavioral perspective. The past 20 years have seen enormous changes in the ways that psychologists conceptualize and study elementary learning processes; however, many of those changes are poorly appreciated by the neuroscience community a...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2000
ISSN: 1072-0502
DOI: 10.1101/lm.7.1.58